Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1993Endocrinology

Stretch-induced atrial natriuretic factor release utilizes a rapidly depleting pool of newly synthesized hormone.

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated rat atria preparation

Comparison

Stretch during a 1-h chase period after double… vs Basal conditions (0.2-g load)

Design

Preclinical

Follow-up

1-h chase period

Authors

HMHalinder S. MangatBrain Trauma Foundation

Discussion

Loading...

Member takes

Implication

Stretch elicits rapid ANF release from new synthesis in atrial tissue; leaves open in vivo relevance and human HF implications.

Structured PICO

P
Population
Isolated rat atria preparation
I
Intervention
Stretch (5-g load) during a 1-h chase period after double isotope labeling
C
Comparator
Basal conditions (0.2-g load)
O
Outcome
Release of immunoreactive ANF and specific activity of [14C]ANF and [3H]ANFsurrogate

The secretory response of ANF to atrial stretch consists of a rapid, short-lived burst of newly synthesized hormone from a rapidly depletable pool.

Cite This Study

Halinder S. Mangat (1993) studied this question.

synapsesocial.com/papers/6a7d7d070da76b3c898c8cdehttps://doi.org/10.1210/endo.133.3.8365374
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein Synthesis and Amino Acid Transport in the Isolated Rabbit Right Ventricular Papillary Muscle: EFFECT OF ISOMETRIC TENSION DEVELOPMENT1972 · 99 citations
  2. 2Aortic perfusion pressure as a determinant of cardiac protein synthesis1984 · 110 citations
  3. 3Vasoactive Intestinal Polypeptide and Thyrotropin-Releasing Hormone Stimulate Newly Synthesized, not Stored, Prolactin*1991 · 14 citations
  4. 4Effect of Growth Hormone-Releasing Factor-44 upon Release of Concurrently Synthesized Hormone by Perifused Rat Pituitary Tissue*1986 · 14 citations
  5. 5The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles1983 · 70 citations