Why the study?
Does mechanical stretch and temperature reduction affect the release of atrial natriuretic factor in isolated rat atria?
Does mechanical stretch and temperature reduction affect the release of atrial natriuretic factor in isolated rat atria?
The release of atrial natriuretic factor from isolated rat atria is temperature-dependent and driven by both the extent and rate of mechanical stretch.
Answers are grounded in this paper and cite their sources.
Rate- and temperature-dependent ANF release in rat atria supports mechanistic inquiry; leaves open translation to human volume regulation or HF.
The effect of continuous and repetitive mechanical stretch on release of immunoreactive atrial natriuretic factor (IR-ANF) was studied in isolated rat atria distended by inflation of miniature balloon catheters. After 10 min incubation, the concentration of IR-ANF in the medium increased in proportion to the degree of continuous atrial stretch. Repetitive atrial expansion induced a rate dependent increase in release of IR-ANF which at the highest rate tested (89 inflations/min) was sixfold greater than that observed with continuous maximal expansion. Comparison of the amount of IR-ANF released from the right or left atrium separately revealed that during continuous and repetitive stretch, both atria contribute equally to the total amount of release IR-ANF. A reduction of bath temperature (37 degrees to 21.5 degrees C) decreased both basal- and stretch-induced IR-ANF release approximately 85%. It was concluded that release of atrial natriuretic factor is temperature-dependent and induced by both the extent and rate of atrial stretch.
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Bilder et al. (1986) studied this question.
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