Key result
Chronotropic stimulation increased immunoreactive atrial natriuretic factor secretion in a manner dependent on pacing frequency and diastolic tension, independent of changes in atrial stretch.
Why the study?
Does chronotropic stimulation directly increase the release of atrial natriuretic factor independently of atrial stretch in isolated rat left atria?
Population
Isolated rat left atria (including atria from reserpinized rats)
Comparison
Electrical pacing at constant resting tension vs Different pacing frequencies and resting tensions
Design
Preclinical
Authors
Loading...
Supports direct chronotropic regulation of atrial natriuretic factor release in isolated atria; leaves open translation to human physiology.
Does chronotropic stimulation directly increase the release of atrial natriuretic factor independently of atrial stretch in isolated rat left atria?
Chronotropic stimulation directly increases the release of atrial natriuretic factor independently of changes in atrial stretch, with the magnitude depending on pacing frequency and diastolic tension.
Bilder et al. (1989) studied this question. Chronotropic stimulation (electrical pacing) was evaluated on Amount of immunoreactive atrial natriuretic factor (IRANF) released. Chronotropic stimulation increased immunoreactive atrial natriuretic factor secretion in a manner dependent on pacing frequency and diastolic tension, independent of changes in atrial stretch.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: