Why the study?
Does volume loading with dextran-40 and myocardial stimulation with isoproterenol improve hemodynamic parameters in patients with shock?
Population
23 patients in shock from hemorrhage, trauma, or sepsis, and 10 healthy controls
Comparison
Volume loading with infusion of dextran-40 and… vs Healthy controls
Design
Cohort
Authors
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Non-responders to dextran-40 volume loading in shock warrant caution with fluids alone; supports hypothesis-generating role for isoproterenol but requires prospective validation.
Does volume loading with dextran-40 and myocardial stimulation with isoproterenol improve hemodynamic parameters in patients with shock?
A significant number of patients in shock exhibit signs of cardiac insufficiency that responds to isoproterenol, suggesting depletion or altered metabolism of endogenous catecholamines.
Carey et al. (1967) studied this question.