Why the study?
Does coronary angiography accurately estimate the degree of coronary artery narrowing compared to necropsy histology in patients with fatal coronary heart disease?
Population
10 patients with fatal coronary heart disease undergoing coronary angiography 0 to 69 days before necropsy
Comparison
Coronary angiography vs Histological evaluation at necropsy
Design
Cross-sectional
Follow-up
0 to 69 days (average 21) between angiography and necropsy
Authors
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Angiography may underestimate narrowing severity in fatal CHD; cross-sectional data leaves open prospective validation against histology.
Does coronary angiography accurately estimate the degree of coronary artery narrowing compared to necropsy histology in patients with fatal coronary heart disease?
Coronary angiography frequently underestimates the severity of coronary artery narrowing compared to histology, likely due to the diffuse nature of atherosclerotic plaquing.
Ernest N. Arnett (1979) studied this question.
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