Population
Sulfolobus solfataricus (crenarchaeon) type III CRISPR systems (Sso-IIID and Sso-IIIB complexes)
Design
Preclinical
Authors
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These archaeal CRISPR findings extend type III mechanism maps; leaves open eukaryotic validation and engineering applications.
The study demonstrates that divergent type III CRISPR systems in Sulfolobus solfataricus utilize multiple nucleic acid cleavage modes, including a universal backbone-mediated RNA cleavage and Cas10-dependent DNA degradation.
Zhang et al. (2016) studied this question.
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