Key result
A longer duration of diabetes (≥10 years) was associated with a nonsignificant increased risk of new-onset heart failure compared to <5 years on multivariate analysis (P=0.056).
Why the study?
The study aimed to investigate the association between diabetes duration and the subsequent occurrence of heart failure in type 2 diabetes mellitus patients without clinical cardiovascular disease.
Does a longer duration of diabetes increase the risk of new-onset HF and all-cause mortality in T2DM patients without clinical cardiovascular disease?
Cohort (n=3,724)
No
Does a longer duration of diabetes increase the risk of new-onset HF and all-cause mortality in T2DM patients without clinical cardiovascular disease?
p-value: p=0.056
A longer duration of diabetes is associated with an increased risk of new-onset heart failure and all-cause mortality in T2DM patients without clinical cardiovascular disease.
Nonsignificant association advises against duration-based HF risk stratification in T2DM; leaves open confirmation in larger prospective cohorts.
We aimed to investigate the association between diabetes duration and the subsequent occurrence of heart failure (HF) in type 2 diabetes mellitus (T2DM) patients without clinical cardiovascular disease.In this single-center, observational cohort study, a total of 3724 T2DM patients were stratified by diabetes duration into three 5-year interval subgroups. The primary outcomes were the occurrence of new-onset HF and all-cause mortality.HF incidence (P < .001) and mortality (P = .001) were significantly higher in patients with a longer duration of diabetes (≥10 years) than in those with a shorter duration (<5 years). On multivariate analysis, diabetes duration ≥10 years was not independently associated with all-cause mortality compared with duration < 5 years, but there was a nonsignificant increased risk of HF in patients with a diabetes duration ≥10 years (P = .056). Poor glycemic control was associated with an increased risk of HF and mortality; statin use was associated with a significantly decreased risk of mortality.Our study indicated that a longer duration of diabetes is associated with an increased risk of new-onset HF occurrence and all-cause mortality in T2DM patients without clinical cardiovascular disease.
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Noh et al. (2019) conducted a cohort in Type 2 diabetes mellitus without clinical cardiovascular disease (n=3,724). Diabetes duration ≥10 years vs. Diabetes duration <5 years was evaluated on New-onset heart failure and all-cause mortality (p=0.056). A longer duration of diabetes (≥10 years) was associated with a nonsignificant increased risk of new-onset heart failure compared to <5 years on multivariate analysis (P=0.056).
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