Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Cells expressing G protein-activated inward rectifier K+ (GIRK) channels

Intervention

Mutation of the conserved RGD sequence to RGE on the GIRK4 subunit

Comparator

Wild-type GIRK channels

Outcome

GIRK current and channel membrane localizationsurrogate

GIRK channels require direct interaction with integrins via a conserved RGD sequence for proper plasma membrane localization and electrical function.

No takes yet. Share an insight, caveat, or question.

RGD-integrin interaction supports GIRK localization and current in model systems; leaves open its relevance to cardiac electrophysiology in vivo.

McPhee et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark

RGD-integrin interaction supports GIRK localization and current in model systems; leaves open its relevance to cardiac electrophysiology in vivo.