Characterization of K Currents in Cultured Human Corporal Smooth Muscle Cells
Population
Homogeneous explant cell cultures of human corpus cavernosum smooth muscle (n=12 cells for resting potential)
Comparison
Stimulation with calcium channel agonist BAY K… vs Baseline/unstimulated state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
K currents may regulate corporal smooth muscle tone; animal data leave open human therapeutic relevance.
Structured PICO
P
Population
Homogeneous explant cell cultures of human corpus cavernosum smooth muscle (n=12 cells for resting potential)
I
Intervention
Stimulation with calcium channel agonist BAY K 8644 or K channel agonist pinacidil
C
Comparator
Baseline/unstimulated state
O
Outcome
Characterization of K currents (resting potential, whole cell outward K currents, single channel recordings)surrogate
Human corporal smooth muscle cells exhibit large whole cell K currents and K channel heterogeneity, suggesting an important role in modulating corporal smooth muscle tone.
Cite This Study
Christ et al. (1993) studied this question.