Why the study?
Does intra-arterial infusion of dopamine or isoproterenol alter renal blood flow and renin secretion in anesthetized dogs?
Population
8 anesthetized dogs
Comparison
Intra-arterial infusion of dopamine and… vs Baseline (before infusion)
Design
Preclinical
Authors
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Supports beta-adrenergic renin stimulation unlike dopamine in dogs; leaves open translation to human renal physiology.
Does intra-arterial infusion of dopamine or isoproterenol alter renal blood flow and renin secretion in anesthetized dogs?
Isoproterenol stimulates renin secretion via beta-adrenergic receptors, whereas dopamine increases renal blood flow without significantly altering renin secretion.
Chokshi et al. (1972) studied this question.
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