Immunization of guinea pigs with enterovirus virions disrupted by heating with sodium dodecyl sulfate produces broadly cross-reactive antibodies, unlike heating alone which produces type-specific antibodies.
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Caution against clinical translation from guinea pig data; supports further exploration of detergent-disrupted virions for broad immunity.
We studied the type specificity of the antisera which were produced in guinea pigs by immunization with heat-disrupted virions of human enteroviruses (echovirus types 7 and 11 and coxsackievirus type B5). When guinea pigs were immunized with heated virions (H particles), the antibodies produced reacted type specifically by complement fixation with the homologous H particles. By contrast, when guinea pigs were immunized with disrupted virions prepared by heating in the presence of sodium dodecyl sulfate, antibodies were produced which reacted broadly. Heterotypic complement-fixing antibody responses of humans to enterovirus infections are discussed.
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Hasegawa et al. (1983) studied this question.
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