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April 1, 1986The Journal of Infectious Diseases

Preparation of a Prototype Inactivated Hepatitis A Virus Vaccine from Infected Cell Cultures

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Why the study?

Does a prototype inactivated hepatitis A virus vaccine elicit antibodies and protect against HAV challenge in animal models?

Population

BS-C-1 cells, guinea pigs, and owl monkeys

Design

Preclinical

Authors

LBLeonard N. BinnLovelace Respiratory Research InstituteWBWilliam H. BancroftJohn Brown UniversitySLStanley M. LemonUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Does not alter human vaccination practice; extends preclinical protection data for inactivated HAV vaccines.

Structured PICO

Does a prototype inactivated hepatitis A virus vaccine elicit antibodies and protect against HAV challenge in animal models?

P
Population
BS-C-1 cells, guinea pigs, and owl monkeys
I
Intervention
Prototype inactivated hepatitis A virus vaccine (HM175 strain, formalin inactivated) given in three doses
O
Outcome
Immunogenicity (antibody elicitation) and protection against virulent HAV challenge (virus shedding in feces, serum alanine aminotransferase levels)surrogate

A prototype inactivated whole virus hepatitis A vaccine prepared from cell culture is immunogenic and protects owl monkeys against virulent HAV challenge.

Cite This Study

Binn et al. (1986) studied this question.

synapsesocial.com/papers/6a7d9d5b33dcb27c99cb4fe3https://doi.org/10.1093/infdis/153.4.749
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Also Consider

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  1. 1Industrial-Scale Production of Inactivated Poliovirus Vaccine Prepared by Culture of Vero Cells on Microcarrier1984 · 77 citations
  2. 2Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage1981 · 154 citations
  3. 3Primary isolation and serial passage of hepatitis A virus strains in primate cell cultures1984 · 112 citations
  4. 4An Inactivated Hepatitis A Virus Vaccine Prepared from Infected Marmoset Liver1978 · 95 citations
  5. 5Propagation of Human Hepatitis A Virus in Cell Culture in Vitro1979 · 392 citations