Key result
Escitalopram treatment (10-20 mg/d) for 8 weeks significantly reduced mean platelet volume and platelet count in patients with major depressive disorder.
Why the study?
Does escitalopram reduce mean platelet volume in patients with major depression?
Does escitalopram reduce mean platelet volume in patients with major depression?
Escitalopram treatment reduces mean platelet volume in patients with major depression, which may have implications for reducing the risk of comorbid ischemic heart disease.
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Supports hypothesis of escitalopram platelet effects on IHD risk in MDD; leaves open confirmation in randomized outcome trials.
Ataoğlu et al. (2009) studied Major depressive disorder (n=32). Escitalopram vs. Healthy controls (at baseline) and pre-treatment baseline was evaluated on Mean platelet volume (MPV) and platelet count. Escitalopram treatment (10-20 mg/d) for 8 weeks significantly reduced mean platelet volume and platelet count in patients with major depressive disorder.
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