Why the study?
Does escitalopram or its metabolites inhibit platelet aggregation in vitro in blood samples from healthy volunteers?
Population
20 healthy volunteers (blood samples used for in vitro testing)
Design
Preclinical
Authors
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Escitalopram's in vitro antiplatelet effects merit human confirmation; leaves open any cardiovascular benefit in depression.
Does escitalopram or its metabolites inhibit platelet aggregation in vitro in blood samples from healthy volunteers?
Escitalopram, but not its major metabolites, exhibits direct antiplatelet effects in vitro, providing a potential mechanistic link for cardiovascular benefits in depressed patients.
Atar et al. (2006) studied this question.
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