Key result
Acute dobutamine stimulation increased heart rate and LV function in naïve mice (p<0.05) but failed to induce further responses in isoprenaline-stressed mice, unmasking early LV dysfunction.
Why the study?
Does acute and sustained β-adrenergic stimulation alter cardiac structure and function in murine models?
Population
Murine models (naïve and stressed mice)
Comparison
Acute β-adrenergic stimulation and sustained… vs Saline infusion and/or injection
Design
Preclinical
Follow-up
Up to 14 days
Authors
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Acute dobutamine may unmask early LV dysfunction in remodeled murine hearts; leaves open translation to human β-adrenergic testing.
Does acute and sustained β-adrenergic stimulation alter cardiac structure and function in murine models?
p-value: p=<0.05
Acute dobutamine stimulation unmasks early signs of LV dysfunction in the remodeled murine heart, even at a stage when basal function is enhanced.
Puhl et al. (2016) studied Murine model of cardiac stress. Dobutamine and Isoprenaline vs. Saline was evaluated on Echocardiographic parameters (heart rate, LVEF, LVFS, wall thickness, LV diameter) (p=<0.05). Acute dobutamine stimulation increased heart rate and LV function in naïve mice (p<0.05) but failed to induce further responses in isoprenaline-stressed mice, unmasking early LV dysfunction.
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