Key result
In Tgαq*44 mice with heart failure, low doses of dobutamine significantly increased inotropic and lusitropic cardiac performance without chronotropic changes, whereas high doses increased heart rate but lost functional reserve.
Why the study?
Does dobutamine stress testing using low and high doses reveal alterations in cardiac function in a mouse model of dilated cardiomyopathy?
Population
Tgαq*44 mice with dilated cardiomyopathy at the stage of advanced heart failure, and wildtype mice
Comparison
Low and high doses of dobutamine vs Wildtype mice and dose-dependent comparisons
Design
Preclinical
Authors
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Low-dose dobutamine effects in this HF mouse model warrant clinical caution; leaves open dose-specific reserve mechanisms for human validation.
Does dobutamine stress testing using low and high doses reveal alterations in cardiac function in a mouse model of dilated cardiomyopathy?
An MRI stress test protocol using low and high doses of dobutamine effectively characterizes altered cardiac functional reserve in a mouse model of advanced heart failure.
Tyrankiewicz et al. (2012) studied Dilated cardiomyopathy at the stage of advanced heart failure. Dobutamine vs. Wildtype mice was evaluated on Inotropic, lusitropic, and chronotropic response to β(1)-adrenergic stimulation assessed by cine MRI. In Tgαq*44 mice with heart failure, low doses of dobutamine significantly increased inotropic and lusitropic cardiac performance without chronotropic changes, whereas high doses increased heart rate but lost functional reserve.
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