September 1, 1997British Journal of PharmacologyOpen Access

Angiotensin II responses of vascular smooth muscle cells from hypertensive rats: enhancement at the level of p42 and p44 mitogen activated protein kinase

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Why the study?

Does angiotensin II stimulation differentially regulate the p42 and p44 MAPK pathway in vascular smooth muscle cells from hypertensive versus normotensive rats?

Population

Vascular smooth muscle cells from spontaneously hypertensive rats (SHR) and normotensive (WKY) controls

Comparison

Angiotensin II and phorbol myristate acetate… vs Vascular smooth muscle cells from normotensive…

Design

Preclinical

Authors

NWNeil WilkieMerck & Co., Inc., Rahway, NJ, USA (United States)LNLeong L. NgHeart Failure & Transplant MBMichael R. BoarderUniversity of Leicester

Discussion

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Implication

Enhanced Ang II-stimulated MAPK activation in SHR VSMCs is hypothesis-generating; leaves open relevance to human hypertension.

Structured PICO

Does angiotensin II stimulation differentially regulate the p42 and p44 MAPK pathway in vascular smooth muscle cells from hypertensive versus normotensive rats?

Population

Vascular smooth muscle cells from spontaneously hypertensive rats (SHR) and normotensive (WKY) controls

Intervention

Angiotensin II (100 nM) and phorbol myristate acetate (100 nM), with or without protein kinase C inhibitor Ro 31-8220 or tyrosine kinase inhibitor genistein

Comparator

Vascular smooth muscle cells from normotensive (WKY) controls

Outcome

Phosphorylation and activation of p42mapk and p44mapksurrogate

Angiotensin II-stimulated MAPK activity is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats via mechanisms involving protein kinase C and tyrosine kinase.

Cite This Study

Wilkie et al. (1997) studied this question.

synapsesocial.com/papers/6a7da245e5379bb2b27d8568 https://doi.org/10.1038/sj.bjp.0701366

Topics

Hypertension management

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Angiotensin II responses of vascular smooth muscle cells from hypertensive rats: enhancement at the level of p42 and p44 mitogen activated protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Angiotensin II responses of vascular smooth muscle cells from hypertensive rats: enhancement at the level of p42 and p44 mitogen activated protein kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider