The successful crystallization of the N-terminal actin binding domain of human fimbrin paves the way for determining the first structure of an actin crosslinking domain.
Crystallization of ABD1 advances structural studies of actin crosslinkers; leaves open relevance to human cardiovascular disease.
We have crystallized the N-terminal actin binding domain (ABD1) of human fimbrin, a representative member of the largest class of actin crosslinking proteins. Diffraction from these crystals is consistent with the orthorhombic space group P2(1)2(1)2(1) (a = 50.03 A, b = 61.24 A, c = 102.30 A). These crystals contain one molecule in the asymmetric unit and diffract to at least 1.9 A resolution. The crystal structure of ABD1 will be the first structure of an actin crosslinking domain.
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Goldsmith et al. (1997) studied this question.
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