Population
Actin filaments decorated with the actin-binding domain of chick smooth muscle alpha-actinin (alpha A1-2)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the functional impact of these actin binding sites on sarcomere mechanics in vivo.
Cryoelectron microscopy reveals that residues 86-117 and 350-375 on adjacent actin monomers form distinct binding sites for alpha-actinin.
McGough et al. (1994) studied this question.
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