Why the study?
Is abnormal platelet Ca2+ handling in essential hypertension associated with cellular Mg2+ deficiency?
Population
30 essential hypertensive patients and 30 sex- and age-matched normotensive controls (n=60)
Design
Case-control
Authors
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Challenges Mg2+ deficiency hypothesis for platelet Ca2+ handling in hypertension; hypothesis-generating, needs prospective confirmation.
Is abnormal platelet Ca2+ handling in essential hypertension associated with cellular Mg2+ deficiency?
The study opposes the hypothesis that abnormal platelet Ca2+ handling in essential hypertension is due to cellular Mg2+ deficiency, as cytosolic free Mg2+ was actually higher in hypertensive patients.
Hiraga et al. (1998) studied this question.
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