Why the study?
Does essential hypertension alter platelet aggregation kinetics and calcium levels compared to normotensive controls?
Population
15 untreated patients with essential hypertension and without detectable atherosclerosis, 18-40 years old…
Design
Case-control
Authors
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Hypertension may associate with platelet changes; leaves open independence from count and any clinical relevance.
Does essential hypertension alter platelet aggregation kinetics and calcium levels compared to normotensive controls?
Platelets in early essential hypertension display an overall increased aggregation potential but diminished sensitivity to ADP, with free calcium levels correlating with blood pressure.
Taylor et al. (1989) studied this question.
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