Key result
A systems genetics analysis in mice identified a locus near Tns3-Hus1 associated with baseline E/A ratio (p = 1.65E-06), which is syntenic to a human locus associated with diastolic function.
p-value: p=1.65E-06
This systems genetics analysis in mice identified novel loci associated with diastolic dysfunction, including regions syntenic to human GWAS findings, providing targets for future basic investigations.
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Hypothesis-generating for diastolic function genetics; leaves open human translation and clinical utility pending validation.
Wang et al. (2019) studied Isoproterenol-induced cardiac diastolic dysfunction (n=104). Isoproterenol vs. Control was evaluated on Genetic locus associated with baseline E/A ratio (near Tns3-Hus1) (p=1.65E-06). A systems genetics analysis in mice identified a locus near Tns3-Hus1 associated with baseline E/A ratio (p = 1.65E-06), which is syntenic to a human locus associated with diastolic function.
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