Key result
Parechovirus A3 emerged as the most frequently detected single picornavirus type in pediatric cerebrospinal fluid, accounting for 26% of all typed detections and surpassing any individual enterovirus type.
Why the study?
Enterovirus and parechovirus species A are the leading reported causes of pediatric central nervous system infections in the United States, prompting an investigation into their molecular epidemiology.
Observational (n=5,362)
No
PeV-A3 emerged as the leading cause of pediatric central nervous system infections among picornaviruses in a 10-year US cohort, highlighting the need for routine PeV-A testing.
Alerts clinicians to parechovirus A3 in pediatric CSF diagnostics; leaves open need for outcome and management studies.
species A (PeV-A), are the leading reported causes of pediatric central nervous system infections in the United States. We investigated the molecular epidemiology of EV and PeV-A over 10 years in cerebrospinal fluid (CSF) collected from children seen at Children's Mercy-Kansas City (CMKC) from 2007 through 2016. The overall prevalence for EV was 16% (862/5,362) and 7% (271/4,016) for PeV. Among all picornavirus CSF detections, EV was 76%, and PeV-A was 24%. Multiple EV types cocirculated each year, with a total of 31 EV types detected in the 10-year period; the majority belonged to EV-B species (96%). Two PeV-A types were detected; PeV-A3 was the dominant PeV-A type (95%). The top five picornaviruses (PeV-A3, 26%; E30, 11%; E6, 10%; E18, 9%; E9, 7%) in the CSF of infants accounted for two-thirds of all detections, and PeV-A3 was the leading picornavirus detected. Routine testing and reporting of PeV-A in addition to EV, especially in children under 6 months old with acute febrile illnesses, could reduce hospital stays and antibiotic usage.
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Sasidharan et al. (2021) conducted an observational in Central Nervous System Infection (n=5,362). Picornavirus (Enterovirus and Parechovirus A) infection was evaluated on Prevalence and molecular epidemiology of Enterovirus and Parechovirus A types in pediatric cerebrospinal fluid. Parechovirus A3 emerged as the most frequently detected single picornavirus type in pediatric cerebrospinal fluid, accounting for 26% of all typed detections and surpassing any individual enterovirus type.
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