Key result
Infants with PeV-A4 central nervous system infections had similar clinical presentations to those with PeV-A3, but exhibited significantly higher maximum temperatures (39.17°C vs 38.82°C, P=0.017).
Why the study?
The prevalence of PeV-A3 among infants with sepsis-like illness and CNS infection is well described, but the contribution of PeV-A4 to infant CNS infection is relatively unexplored.
Observational (n=45)
No
Absolute Event Rate: 39.17% vs 38.82%
p-value: p=0.017
PeV-A4 can cause central nervous system infections and sepsis-like illness in young infants, presenting similarly to PeV-A3 but with slightly higher maximum temperatures and lower peripheral white blood cell counts.
May aid strain differentiation in febrile infants; hypothesis-generating and requires validation in larger cohorts.
Among known parechovirus (PeV) types infecting humans, PeV-A3 (formerly HPeV3) and PeV-A1 (formerly HPeV1) are associated with pediatric central nervous system (CNS) infections. The prevalence of PeV-A3 among hospitalized infants with sepsis-like illness and viral CNS infection is well described; however, the contribution of PeV-A4 to infant CNS infection is relatively unexplored.
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Sasidharan et al. (2019) conducted an observational in Parechovirus central nervous system infection (n=45). Parechovirus A4 (PeV-A4) infection vs. Parechovirus A3 (PeV-A3) infection was evaluated on Maximum temperature (Tmax) during hospitalization (p=0.017). Infants with PeV-A4 central nervous system infections had similar clinical presentations to those with PeV-A3, but exhibited significantly higher maximum temperatures (39.17°C vs 38.82°C, P=0.017).
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