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March 28, 2025European Heart Journal - Case ReportsOpen Access

Transvenous DDD pacemaker implantation and medication stabilized a 60-year-old woman with unrepaired d-TGA, resolving syncope and heart failure with no recurrence over 2 years of follow-up.

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Population

One 60-year-old woman with unrepaired d-TGA, ASD, and PAPVR

Design

Case report

Follow-up

2 years

Key result

Transvenous DDD pacemaker implantation and medication stabilized a 60-year-old woman with unrepaired d-TGA, resolving syncope and heart failure with no recurrence over 2 years of follow-up.

Authors

TMTomoko Machino‐OhtsukaMIMiyako IgarashiNKNaoto Kawamatsu

Discussion

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Overview

May inform adult CHD prognosis counseling; leaves open larger cohort studies on unrepaired d-TGA survival.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 60-year-old woman with unrepaired d-TGA, an unrestricted atrial septal defect, and partial anomalous pulmonary venous return presenting with recurrent syncope and heart failure.
I
Intervention
Transvenous DDD pacemaker implantation (systemic right ventricle septal pacing) with atrioventricular delay optimization, amiodarone, and apixaban therapy.
O
Outcome
Improvement in heart failure symptoms, suppression of atrial tachycardias, resolution of syncope, and absence of thromboembolic events or recurrence over 2 years.

Endocardial pacing with atrioventricular delay optimization and medical therapy successfully stabilized a rare case of a 60-year-old with unrepaired d-TGA, bradytachyarrhythmia, and systemic right ventricular dysfunction.

Cite This Study

Machino‐Ohtsuka et al. (2025) conducted a case report in Unrepaired D-transposition of the great arteries, atrial septal defect, and partial anomalous pulmonary venous return (n=1). Transvenous DDD pacemaker implantation was evaluated. Transvenous DDD pacemaker implantation and medication stabilized a 60-year-old woman with unrepaired d-TGA, resolving syncope and heart failure with no recurrence over 2 years of follow-up.

synapsesocial.com/papers/6a7da8dd0210b8d50ccda468https://doi.org/10.1093/ehjcr/ytaf170
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Navigating the clinical complexity of acute heart failure in an untreated adult with dextrotransposition of the great arteries (D-TGA) and multiple cardiac anomalies: a case report and review of literature2025
  2. 2Atrial arrhythmia predicts late events and mortality in patients with D-transposition of the great arteries and atrial switch repair2024 · 4 citations
  3. 3Ventricular fibrillation in congenitally corrected transposition of great arteries treated with pacing: a case report2019 · 5 citations
  4. 4Long-term results after atrial repair of transposition of the great arteries in early infancy.1982 · 63 citations
  5. 5Pacemaker and Defibrillation Implantation in Patients with Transposition of the Great Arteries2017 · 2 citations