Why the study?
Patients with D-transposition of the great arteries and atrial switch experience late morbidity and mortality related to atrial arrhythmias and systemic right ventricular failure, prompting analysis of the influence of atrial arrhythmias on long-term outcomes.
Do atrial arrhythmias predict death, cardiac transplantation, or heart failure hospitalization in patients with D-TGA and atrial switch repair?
Population
148 patients with D-TGA and atrial switch followed at a tertiary care center
Comparison
Presence vs absence of atrial arrhythmias
Design
Retrospective cohort study
Follow-up
12 ± 9.8 years
Key result
In patients with D-TGA and atrial switch, atrial fibrillation predicted an increased risk of death or cardiac transplantation (HR 3.50, p=0.006).
Authors
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Atrial arrhythmias may signal higher risk in D-TGA atrial-switch patients; leaves open whether rhythm control alters SRV outcomes.
Cohort (n=148)
No
Do atrial arrhythmias predict death, cardiac transplantation, or heart failure hospitalization in patients with D-TGA and atrial switch repair?
Hazard Ratio: 3.5
p-value: p=0.006
In patients with D-TGA and atrial switch repair, atrial fibrillation strongly predicts death or cardiac transplantation, while atrial tachycardia and flutter predict heart failure hospitalization.
Chiriac et al. (2024) conducted a cohort in D-transposition of the great arteries (D-TGA) and atrial switch (n=148). Atrial fibrillation vs. No atrial fibrillation was evaluated on Death or cardiac transplantation (HR 3.50, p=0.006). In patients with D-TGA and atrial switch, atrial fibrillation predicted an increased risk of death or cardiac transplantation (HR 3.50, p=0.006).