Key result
The prevalence of congenital coronary anomalies was not significantly higher in D-TGA patients with atrial switch surgery who experienced a major adverse cardiovascular event compared to historical controls (26.7% vs 28.7%, p=0.89).
Why the study?
Myocardial ischemia is implicated in sudden death after atrial switch for D-TGA, but whether coronary anomalies associate with adverse events remained unclear.
Does the presence of abnormal coronary anatomy predict serious cardiac adverse events in adults with D-TGA and atrial switch surgery?
Comparison
MACE cohort vs 647 historical controls with D-TGA
Design
Multicenter observational study
Authors
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No support for coronary anomalies predicting MACE in D-TGA atrial switch; hypothesis-generating and requires prospective validation.
Observational (n=45)
Yes
Does the presence of abnormal coronary anatomy predict serious cardiac adverse events in adults with D-TGA and atrial switch surgery?
Absolute Event Rate: 26.7% vs 28.7%
p-value: p=0.89
Perreux et al. (2020) conducted an observational in D-transposition of the great arteries (D-TGA) with atrial switch surgery (n=45). Major adverse cardiovascular event (MACE) vs. Historical controls with D-TGA was evaluated on Prevalence of congenital coronary anomalies (p=0.89). The prevalence of congenital coronary anomalies was not significantly higher in D-TGA patients with atrial switch surgery who experienced a major adverse cardiovascular event compared to historical controls (26.7% vs 28.7%, p=0.89).
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