Why the study?
Although replaced by the arterial switch operation, the adult cohort with D-TGA after atrial switch repair remains large, requiring strict management of late complications and identification of potential long-term mortality risk factors.
Do clinical factors such as NYHA class ≥III, tricuspid regurgitation, and the Mustard procedure increase long-term mortality in patients with D-TGA after atrial switch repair?
Population
2912 patients with D-TGA after Mustard or Senning procedures across 22 cohort studies
Comparison
Potential long-term mortality risk factors vs their absence
Design
Meta-analysis of retrospective and prospective cohort studies
Follow-up
At least 5 years mean/median follow-up
Authors
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NYHA ≥III and moderate tricuspid regurgitation flag high mortality risk post-atrial switch; confirms key predictors and supports prospective risk-stratification trials.
Do clinical factors such as NYHA class ≥III, tricuspid regurgitation, and the Mustard procedure increase long-term mortality in patients with D-TGA after atrial switch repair?
In patients with D-TGA after atrial switch repair, NYHA class ≥III, moderate/severe tricuspid regurgitation, right ventricular dysfunction, complex anatomy, and the Mustard procedure are significant risk factors for long-term mortality.
Nartowicz et al. (2023) studied this question.
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