April 1, 1974Clinical Science

Comparison of the Renin Response to Dopamine and Noradrenaline in Normal Subjects and Patients with Autonomic Insufficiency

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Why the study?

Does dopamine infusion compared to noradrenaline infusion affect plasma renin activity in normal subjects and patients with autonomic insufficiency?

Population

9 subjects

Comparison

Dopamine infusion vs Noradrenaline infusion

Design

Other

Follow-up

Acute (4 minutes)

Authors

CWChristopher S. WilcoxVascular Medicine MAM. J. AminoffCourtauld Institute of Art AKA. B. KurtzUniversity of Zurich

Discussion

Member takes

Implication

Dopamine receptor stimulation elicits renin release despite autonomic failure; leaves open whether this mechanism informs therapy for low-renin states.

Structured PICO

Does dopamine infusion compared to noradrenaline infusion affect plasma renin activity in normal subjects and patients with autonomic insufficiency?

Population

9 subjects (3 with Shy-Drager syndrome, 3 with Parkinson's disease and normal autonomic reflexes, and 3 healthy volunteers)

Intervention

Dopamine infusion (step-wise for 4 min until a 30% rise in systolic blood pressure occurred)

Comparator

Noradrenaline infusion (step-wise for 4 min until a 30% rise in systolic blood pressure occurred)

Outcome

Plasma renin activity (PRA)surrogate

Stimulation of dopamine receptors can release renin, indicating that inadequate renin stores do not explain the low plasma renin activity found in patients with autonomic failure.

Cite This Study

Wilcox et al. (1974) studied this question.

synapsesocial.com/papers/6a7da93c482b22b9a6ac7eee https://doi.org/10.1042/cs0460481

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Implication

Dopamine receptor stimulation elicits renin release despite autonomic failure; leaves open whether this mechanism informs therapy for low-renin states.