Key result
Isoproterenol infusion in patients with autonomic failure resulted in more negative blood pressure response slopes and failed to increase plasma NE or PRA compared to normal subjects.
Why the study?
Does isoproterenol infusion elicit different cardiovascular, plasma norepinephrine, and plasma renin responses in patients with autonomic failure compared to normal subjects?
Population
Patients with autonomic failure (multiple system atrophy and pure autonomic failure) and normal subjects
Comparison
Isoproterenol infusion vs Normal subjects
Design
Cross-sectional
Authors
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Suggests supersensitivity and baroreflex impairment in autonomic failure; hypothesis-generating for diagnostic isoproterenol testing.
Observational
Does isoproterenol infusion elicit different cardiovascular, plasma norepinephrine, and plasma renin responses in patients with autonomic failure compared to normal subjects?
Patients with autonomic failure exhibit impaired baroreflex modulation and beta-adrenergic receptor supersensitivity, with absent reflexive norepinephrine and renin responses to isoproterenol.
Baser et al. (1991) conducted an observational in Autonomic failure. Isoproterenol infusion vs. Normal subjects was evaluated on Cardiovascular, plasma norepinephrine (NE), and plasma renin (PRA) responses. Isoproterenol infusion in patients with autonomic failure resulted in more negative blood pressure response slopes and failed to increase plasma NE or PRA compared to normal subjects.
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