Key result
Hypertension was associated with a significantly decreased number of lenticulostriate artery stems detected by 3D-TOF-MRA compared to nonhypertensive volunteers (4.7 vs 6.3, p<0.001).
Why the study?
Is hypertension associated with a decreased number of lenticulostriate arteries as visualized by high-resolution 3T 3D-TOF-MRA?
Cross-Sectional (n=246)
No
Is hypertension associated with a decreased number of lenticulostriate arteries as visualized by high-resolution 3T 3D-TOF-MRA?
Absolute Event Rate: 4.7% vs 6.3%
p-value: p=<0.001
High-resolution 3T 3D-TOF-MRA demonstrates that hypertension is associated with a significantly reduced number of lenticulostriate arteries, particularly in younger patients.
Should not change hypertension management; leaves open causal role and prognostic value of lenticulostriate counts.
BACKGROUND AND PURPOSE: Hypertension, one of the most important risk factors for strokes, is associated with altered arterial anatomy and function. In this study, we compared the visualization of the LSAs by 3T 3D-TOF-MRA and DSA and quantitatively examined the LSAs in patients with hypertension by using 3D-TOF-MRA. MATERIALS AND METHODS: We first examined 126 patients with 3D-TOF-MRA and DSA and determined the number of LSAs. In addition, we examined 60 patients with hypertension and 60 nonhypertensive volunteers with 3D-TOF-MRA and determined the quantitative differences between the LSAs of these 2 groups. RESULTS: The mean number of LSA stems visualized by DSA and 3D-TOF-MRA on 1 side was 4.1 ± 0.74 and 3.9 ± 0.94, respectively (P = .0617). The average number of LSA stems on both sides was 4.7 ± 0.8 in patients with hypertension and 6.3 ± 1.9 in nonhypertensive volunteers (P < .0001). The mean number of LSAs in the young hypertensive group (<50 years of age) and its age-matched nonhypertensive group was 4.8 ± 1.1 and 7.6 ± 1.2, respectively (P < .0001) and that in the old hypertensive group (≥50 years of age) and its age-matched nonhypertensive group was 4.6 ± 0.9 and 5.0 ± 1.0, respectively (P = .1088). CONCLUSIONS: LSA detection showed good correlation between 3T 3D-TOF-MRA and DSA. As determined by 3D-TOF-MRA, there was a significant decrease in the number of LSA stems in patients with hypertension compared with that in nonhypertensive volunteers; moreover, the difference in young subjects was more than that in the elderly.
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Chen et al. (2011) conducted a cross-sectional in Hypertension (n=246). Hypertension vs. Nonhypertensive volunteers was evaluated on Average number of lenticulostriate artery (LSA) stems on both sides (p=<0.001). Hypertension was associated with a significantly decreased number of lenticulostriate artery stems detected by 3D-TOF-MRA compared to nonhypertensive volunteers (4.7 vs 6.3, p<0.001).
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