Key result
Overexpression of c-Flip in transgenic mice significantly reduced left ventricular hypertrophy and the induction of the cardiac fetal gene program in response to pressure overload.
Population
FVB/N strain mice (transgenic overexpressing c-Flip in the heart and wild-type)
Comparison
Transverse aortic constriction-induced pressure… vs Transverse aortic constriction-induced pressure…
Design
Preclinical
Authors
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Hypothesis-generating for c-Flip modulation in pressure-overload states; should not yet change clinical practice.
Overexpression of c-Flip reduces cardiac hypertrophy in response to pressure overload in a mouse model, suggesting it is a key regulator of the cardiac response to ventricular pressure overload.
Giampietri et al. (2008) studied Cardiac hypertrophy. c-Flip overexpression vs. Wild-type mice was evaluated on Left ventricular hypertrophy and cardiac function after TAC. Overexpression of c-Flip in transgenic mice significantly reduced left ventricular hypertrophy and the induction of the cardiac fetal gene program in response to pressure overload.
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