Key result
Higher revascularization-associated ejection fraction improvement was associated with lower mortality, with patients in the highest delta-EF category having 27% (95% CI, 19%-34%) lower mortality.
Why the study?
Coronary revascularization is recommended for ischemic cardiomyopathy, but the relations of revascularization-associated EF change to subsequent outcomes have not been elucidated.
Does improvement in ejection fraction following coronary revascularization reduce death and heart failure hospitalization in veterans?
Population
10 071 veterans undergoing first PCI or coronary artery bypass grafting with pre- and post-procedure EF measured
Comparison
delta-EF evaluated as a continuous measure and across 5 categories
Design
Observational cohort study
Follow-up
Mean/maximum 5/14 years
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EF gains after revascularization may stratify mortality risk; hypothesis-generating and requires randomized confirmation.
Cohort (n=10,071)
Does improvement in ejection fraction following coronary revascularization reduce death and heart failure hospitalization in veterans?
Effect estimate: 27% reduction (95% CI 19-34)
Improvement in left ventricular ejection fraction after coronary revascularization is associated with reduced long-term mortality and heart failure hospitalizations, particularly after PCI.
A 2022 study conducted a cohort in Ischemic cardiomyopathy undergoing first PCI or CABG (n=10,071). Change in Left Ventricular Ejection Fraction (delta-EF) vs. Lowest delta-EF category was evaluated on Death (27% reduction, 95% CI 19-34). Higher revascularization-associated ejection fraction improvement was associated with lower mortality, with patients in the highest delta-EF category having 27% (95% CI, 19%-34%) lower mortality.
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