Key result
Morin and/or hesperidin pretreatment prevented oxidative stress in kidney tissue of cisplatin-treated rats by increasing NOx levels and CAT activity, and decreasing MPO activity.
Why the study?
Does morin and/or hesperidin pretreatment prevent oxidative stress in cisplatin-induced nephrotoxicity in Wistar rats?
Does morin and/or hesperidin pretreatment prevent oxidative stress in cisplatin-induced nephrotoxicity in Wistar rats?
Morin and hesperidin pretreatment may protect against cisplatin-induced nephrotoxicity by reducing oxidative stress.
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Hypothesis-generating for morin/hesperidin renoprotection in cisplatin models; leaves open human translation.
Kaan Kaltalıoğlu (2016) studied Cisplatin-induced nephrotoxicity (n=42). Morin and/or hesperidin vs. Control and cisplatin alone was evaluated on Oxidative stress markers (MDA, NOx, GSH, MPO, CAT, SOD). Morin and/or hesperidin pretreatment prevented oxidative stress in kidney tissue of cisplatin-treated rats by increasing NOx levels and CAT activity, and decreasing MPO activity.
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