Why the study?
Does sex hormone modulation affect the development of left ventricular hypertrophy in sinoaortic denervated rats?
Population
Male and female baroreceptor-denervated (sinoaortic denervated) rats
Comparison
Castration with or without testosterone or… vs Age- and sex-matched sham-operated rats; intact…
Design
Preclinical
Follow-up
15 days
Authors
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No clinical translation from this rat model; leaves open sex hormone roles in pressure-independent LV hypertrophy.
Does sex hormone modulation affect the development of left ventricular hypertrophy in sinoaortic denervated rats?
In a rat model of sinoaortic denervation, testosterone facilitates and estradiol inhibits the development of left ventricular hypertrophy independent of blood pressure.
Cabral et al. (1988) studied this question.
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