Why the study?
Does Angiotensin II stimulate VEGF mRNA translation via reactive oxygen species production in proximal tubular epithelial cells?
Population
Proximal tubular epithelial (MCT) cells
Comparison
Angiotensin II exposure, with or without… vs Control
Design
Preclinical
Authors
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ROS inhibition blocks ANG II-driven VEGF translation in tubular cells; leaves open relevance to human kidney disease.
Does Angiotensin II stimulate VEGF mRNA translation via reactive oxygen species production in proximal tubular epithelial cells?
Angiotensin II stimulates VEGF mRNA translation in proximal tubular epithelial cells via reactive oxygen species production, likely through NAD(P)H oxidase activation.
Féliers et al. (2005) studied this question.
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