Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial
Why the study?
Does intravenous fenoldopam reduce diastolic blood pressure in patients with hypertensive emergencies?
Population
107 emergency department patients with true hypertensive emergencies.
Comparison
Intravenous fenoldopam at fixed doses of 0.03… vs Intravenous fenoldopam at the lowest dose of…
Design
RCT, Randomized to one of four fixed doses, Double-blinded
Follow-up
Up to 48 hours
Authors
Discussion
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Implication
Supports titrated fenoldopam use in hypertensive emergencies; confirms dose-response efficacy in this RCT.
Structured PICO
Does intravenous fenoldopam reduce diastolic blood pressure in patients with hypertensive emergencies?
P
Population
107 emergency department patients with true hypertensive emergencies (sustained diastolic blood pressure ≥120 mm Hg and evidence of target organ compromise).
I
Intervention
Intravenous fenoldopam at fixed doses of 0.03, 0.1, or 0.3 µg/kg/min for 24 hours.
C
Comparator
Intravenous fenoldopam at the lowest dose of 0.01 µg/kg/min for 24 hours.
O
Outcome
Magnitude of diastolic blood pressure reduction after four hours of fenoldopam treatment compared with the lowest-dose group.surrogate
Intravenous fenoldopam provides safe, dose-dependent reduction of diastolic blood pressure in patients presenting with hypertensive emergencies.
Cite This Study
Tumlin et al. (2000) studied this question.