Why the study?
Does fenoldopam intravenous infusion reduce blood pressure in patients with mild-to-moderate essential hypertension?
Population
33 patients with mild-to-moderate essential hypertension
Comparison
Fenoldopam intravenous infusion at a fixed rate… vs Placebo intravenous infusion for 48 hours
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
48 hours of infusion and 24 hours post-infusion
Authors
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Supports low-dose fenoldopam infusion for BP reduction in mild-to-moderate hypertension; confirms dose-dependent efficacy in this RCT.
Does fenoldopam intravenous infusion reduce blood pressure in patients with mild-to-moderate essential hypertension?
Continuous intravenous infusion of fenoldopam for 48 hours effectively and safely reduces blood pressure in patients with mild-to-moderate hypertension without causing rebound hypertension upon discontinuation.
Addison A. Taylor (1999) studied this question.
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