Key result
Endurance training significantly increased left ventricular mass/body mass ratio in both congenic and LOU rats (P<0.05), with no correlation to plasma ACE activity.
Why the study?
Does endurance training induce left ventricular growth differently based on ACE genotype and plasma activity in rats?
Does endurance training induce left ventricular growth differently based on ACE genotype and plasma activity in rats?
Absolute Event Rate: 3.7% vs 3%
p-value: p=<0.05
In a rat model, training-induced left ventricular hypertrophy is not associated with plasma ACE activity, suggesting ACE genotype may not drive exercise-induced cardiac growth.
Training-induced LV hypertrophy in rats is independent of plasma ACE activity; hypothesis-generating for ACE genotype's role in human exercise cardiac remodeling.
AIM: The aim of this study was to determine the influence of angiotensin-converting enzyme (ACE) genotype on left ventricular growth after endurance training, in ACE congenic rats with plasma ACE activity twice as high as the donor strain (LOU), thus mimicking the ACE I/D polymorphism observed in humans. METHODS: LOU and congenic rats (n = 12) were submitted to an endurance training on a treadmill for 7 weeks, while similar LOU and congenic rats (n = 10) constituted the control groups. Blood pressure, skeletal muscle citrate synthase activity, plasma and left ventricular ACE activity were assessed, and echocardiography was performed before and after the training. RESULTS: Angiotensin-converting enzyme plasmatic activity of congenic rats (188.2 +/- 26.6 in controls and 187.1 +/- 22.6 IU in trained rats respectively) was twofold that of the LOU strain (91.9 +/- 23.3 in controls, and 88.3 +/- 18.1 IU in trained rats respectively). After training, congenic and LOU rats showed a similar significant increase in citrate synthase activity (P < 0.05), and in the left ventricular mass/body mass ratio x 10(3): 3.7 +/- 0.3 and 3.6 +/- 0.6 in the trained congenic and LOU groups, respectively, vs. 3.0 +/- 0.1 and 2.9 +/- 0.2 in the control congenic and LOU groups respectively (P < 0.05). There was no significant correlation between ACE plasma activity and left ventricular mass in trained or untrained congenic rats. CONCLUSION: We conclude that training-induced left ventricular growth is not associated with plasma ACE activity in congenic rats.
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Zalvidéa et al. (2008) studied Left ventricular growth (n=22). Endurance training on a treadmill vs. Control group (no training) was evaluated on Left ventricular mass/body mass ratio x 10(3) (p=<0.05). Endurance training significantly increased left ventricular mass/body mass ratio in both congenic and LOU rats (P<0.05), with no correlation to plasma ACE activity.
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