August 5, 1997Circulation
Association of Angiotensin-Converting Enzyme Gene I/D Polymorphism With Change in Left Ventricular Mass in Response to Physical Training
Why the study?
Does the ACE I/D polymorphism affect the change in left ventricular mass in response to physical training in male Caucasian military recruits?
Population
140 male Caucasian military recruits
Comparison
10-week physical training period vs Comparison between ACE genotypes and baseline…
Design
Cohort
Follow-up
10 weeks
Authors
Discussion
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Implication
DD genotype may drive greater exercise LV hypertrophy in young men; hypothesis-generating and requires prospective validation before any clinical use.
Key Points
- To determine whether the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism influences left ventricular hypertrophy in response to physical training.
- Evaluated male Caucasian military recruits over a 10-week standardized physical training program.
- Measured echocardiographic left ventricular dimensions and mass (n=140), electrocardiographic LV hypertrophy (n=121), and plasma brain natriuretic peptide (BNP) levels (n=49) before and after training.
- Left ventricular mass increased overall by 18% following training (P<.0001), with increases of +2.0 g in II, +38.5 g in ID, and +42.3 g in DD genotypes (P<.0001).
- Electrocardiographic left ventricular hypertrophy increased significantly only in DD individuals, rising from 6 of 24 before training to 11 of 24 after training (P<.01).
- Plasma brain natriuretic peptide increased by 56.0 pg/mL in participants with the DD genotype compared with an 11.5 pg/mL increase in those with the II genotype (P<.001).
Structured PICO
Does the ACE I/D polymorphism affect the change in left ventricular mass in response to physical training in male Caucasian military recruits?
P
Population
140 male Caucasian military recruits
I
Intervention
10-week physical training period (analyzed by ACE I/D genotype: II, ID, DD)
C
Comparator
Comparison between ACE genotypes (II, ID, DD) and baseline measurements
O
Outcome
Change in echocardiographically determined left ventricular masssurrogate
The ACE DD genotype is associated with a significantly greater exercise-induced left ventricular hypertrophic response compared to the II genotype in young men.
Cite This Study
Montgomery et al. (1997) studied this question.