What question did this study set out to answer?

To provide a centralized, open-access database resource integrating genomic, functional, and phenotypic data for the laboratory mouse to advance human disease research.

November 26, 2013Nucleic Acids ResearchOpen Access

The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

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Authors

JBJudith A. BlakeAustralian Institute of Tropical Health and Medicine CBCarol J. BultJackson Laboratory JEJanan T. EppigJackson Laboratory

Discussion

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Implication

Database report uncovers integrated genomic and phenotypic knowledge in the laboratory mouse, suggesting improved translation to human disease mechanisms.

Key Points

To provide a centralized, open-access database resource integrating genomic, functional, and phenotypic data for the laboratory mouse to advance human disease research.
Integrated manual and computational genomic annotations from NCBI, Ensembl, and Vega/HAVANA pipelines.
Curated functional classifications using Gene Ontology terms and compiled phenotype-to-human disease associations.
Incorporated the GRCm38 mouse genome assembly alongside high-throughput phenotyping datasets and comparative vertebrate genomic maps.
Cataloged a comprehensive collection of mouse genes, functional RNAs, quantitative trait loci, and heritable phenotypes within a unified system.
Expanded access to multi-species comparative data across vertebrate genomes to facilitate evolutionary and functional modeling.
Provided freely accessible, standardized curated datasets connecting mouse experimental models directly to human clinical pathologies.

Cite This Study

Blake et al. (2013) studied this question.

synapsesocial.com/papers/6a7dc087a76b9ebabb0453c2 https://doi.org/10.1093/nar/gkt1225

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November 26, 2013Nucleic Acids ResearchOpen Access

The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse

View Full Paper

Ask AI

Bookmark

Authors

JBJudith A. BlakeAustralian Institute of Tropical Health and Medicine CBCarol J. BultJackson Laboratory JEJanan T. EppigJackson Laboratory

Discussion

Member takes

Implication

Database report uncovers integrated genomic and phenotypic knowledge in the laboratory mouse, suggesting improved translation to human disease mechanisms.

Key Points

To provide a centralized, open-access database resource integrating genomic, functional, and phenotypic data for the laboratory mouse to advance human disease research.
Integrated manual and computational genomic annotations from NCBI, Ensembl, and Vega/HAVANA pipelines.
Curated functional classifications using Gene Ontology terms and compiled phenotype-to-human disease associations.
Incorporated the GRCm38 mouse genome assembly alongside high-throughput phenotyping datasets and comparative vertebrate genomic maps.
Cataloged a comprehensive collection of mouse genes, functional RNAs, quantitative trait loci, and heritable phenotypes within a unified system.
Expanded access to multi-species comparative data across vertebrate genomes to facilitate evolutionary and functional modeling.
Provided freely accessible, standardized curated datasets connecting mouse experimental models directly to human clinical pathologies.

Cite This Study

Blake et al. (2013) studied this question.

synapsesocial.com/papers/6a7dc087a76b9ebabb0453c2 https://doi.org/10.1093/nar/gkt1225

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