Why the study?
Does late-onset hypertension alter myocardial microvessels in middle-aged and senescent rats?
Population
Middle-aged (15 months) and senescent (24 months) rats
Comparison
One-kidney, figure-8 renal wrap hypertension of… vs Control rats
Design
Preclinical
Follow-up
3 months
Authors
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May limit maximal myocardial perfusion in late-onset hypertension; hypothesis-generating for human translation.
Does late-onset hypertension alter myocardial microvessels in middle-aged and senescent rats?
Late-onset hypertension in older rats induces left ventricular wall remodeling and microvascular alterations that likely limit maximal myocardial flow and oxygen supply.
Tomanek et al. (1990) studied this question.
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