Key result
Experimental hypertension and aging in rats reduced small arteriolar endpoints and anastomotic connections, while caloric restriction prevented these vascular changes in older rats.
Why the study?
Does caloric restriction prevent microvascular alterations in aging rats?
Population
Spontaneously hypertensive rats and old Brown-Norway rats
Design
Preclinical
Authors
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Caloric restriction may attenuate microvascular rarefaction in aged hypertensive rats; hypothesis-generating for human translation.
Does caloric restriction prevent microvascular alterations in aging rats?
Aging and hypertension are associated with microvascular morphological changes and reduced short-term cardiovascular control in rat models, which may be prevented by caloric restriction.
Hutchins et al. (1996) conducted a review in Experimental hypertension and aging. Caloric restriction was evaluated on Microvascular caliber (vasomotion), blood pressure, and heart rate variations. Experimental hypertension and aging in rats reduced small arteriolar endpoints and anastomotic connections, while caloric restriction prevented these vascular changes in older rats.
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