Increased Cardiac Troponin I As Measured by a High-Sensitivity Assay Is Associated with High Odds of Cardiovascular Death: The Minnesota Heart Survey
Key result
Increased high-sensitivity cardiac troponin I was associated with significantly higher adjusted odds of cardiovascular death (OR 8.53; 95% CI 1.68-43).
Why the study?
Are increased levels of novel biomarkers (hs-cTnI, NT-proBNP, hs-CRP) associated with higher odds of cardiovascular mortality in a community-based population?
Population
n=464 participants from the Minnesota Heart Survey, a population-based study of cardiovascular disease risk…
Comparison
Increased levels of novel biomarkers including… vs Normal or lower levels of the respective…
Design
Case-control
Follow-up
8-15 years (median 7.2 years survival for cases)
Authors
Discussion
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Member takes
Implication
Elevated hs-cTnI may flag higher cardiovascular mortality risk in community adults; hypothesis-generating for risk stratification pending prospective validation.
Study Design
Type
Case-Control (n=464)
Structured PICO
Are increased levels of novel biomarkers (hs-cTnI, NT-proBNP, hs-CRP) associated with higher odds of cardiovascular mortality in a community-based population?
P
Population
464 participants from the Minnesota Heart Survey, including 211 who died of cardiovascular causes and 253 matched controls, followed for 8-15 years.
E
Exposure
Increased levels of novel biomarkers including high-sensitivity cardiac troponin I (hs-cTnI), N-terminal pro-B type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP).
C
Comparator
Normal or lower levels of the respective biomarkers.
O
Outcome
Cardiovascular mortality (cardiovascular heart disease, stroke, congestive heart failure) after 8-15 years of follow-up.hard clinical
Main Result
Odds Ratio: 8.53 (95% CI 1.68–43)
Absolute Event Rate: 8.7% vs 1%
p-value: p=<0.001
High-sensitivity cardiac troponin I, along with NT-proBNP and hs-CRP, is strongly associated with cardiovascular mortality in a community-based population.
Cite This Study
Apple et al. (2012) conducted a case-control in Cardiovascular mortality (n=464). Increased high-sensitivity cardiac troponin I (hs-cTnI) vs. Normal hs-cTnI levels was evaluated on Cardiovascular mortality (OR 8.53, 95% CI 1.68-43, p=<0.001). Increased high-sensitivity cardiac troponin I was associated with significantly higher adjusted odds of cardiovascular death (OR 8.53; 95% CI 1.68-43).