Circulating Troponin As Measured by a Sensitive Assay for Cardiovascular Risk Assessment in Primary Prevention
Key result
Increased circulating cardiac troponin I concentrations were associated with increased all-cause mortality and incident MACE over 5 years, improving risk prediction over established risk factors.
Why the study?
Does measuring circulating cardiac troponin I improve risk prediction for incident MACE and mortality in individuals free of known cardiovascular disease?
Population
5388 individuals free of known cardiovascular disease recruited into the DETECT study
Comparison
Measurement of circulating cardiac troponin I… vs Traditional risk factor assessment
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
May enhance risk stratification in primary prevention; leaves open whether measurement changes management or outcomes.
Study Design
Type
Cohort (n=5,388)
Structured PICO
Does measuring circulating cardiac troponin I improve risk prediction for incident MACE and mortality in individuals free of known cardiovascular disease?
P
Population
5,388 individuals free of known cardiovascular disease followed for 5 years.
E
Exposure
Measurement of circulating cardiac troponin I (cTnI) using a sensitive assay
C
Comparator
Traditional risk factor assessment (with or without NT-proBNP and hsCRP)
O
Outcome
Incident major adverse cardiovascular events (MACE) and all-cause mortality during 5 years of follow-upcomposite
Measuring cTnI with a sensitive assay improves cardiovascular risk prediction beyond traditional risk factors in a primary prevention cohort.
Cite This Study
Leistner et al. (2011) conducted a cohort in Cardiovascular risk (n=5,388). Circulating cardiac troponin I (cTnI) vs. Lower or undetectable cTnI concentrations was evaluated on Incident major adverse cardiovascular events (MACE) and all-cause mortality. Increased circulating cardiac troponin I concentrations were associated with increased all-cause mortality and incident MACE over 5 years, improving risk prediction over established risk factors.