Key result
Non-normal blood pressure at ages 45-54 accounted for a population attributable fraction of 15.3% (95% CI 6.9-22.3) for dementia by age 80, with associations persisting through age 75.
Why the study?
The fraction of dementia attributable to hypertension might vary depending on the age of the population considered and the age through which dementia occurs.
Does hypertension at different life stages contribute to the population attributable fraction of dementia?
Population
Atherosclerosis Risk in Communities study participants evaluated across age groups 45-84
Comparison
Hypertension assessed at ages 45-54, 55-64, 65-74, and 75-84 vs normal blood pressure
Design
Prospective cohort study
Follow-up
32-year follow-up
Authors
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Midlife hypertension may explain larger dementia PAF than later assessment; leaves open optimal BP control timing for prevention.
Cohort
Yes
Does hypertension at different life stages contribute to the population attributable fraction of dementia?
Effect estimate: PAF 15.3% (95% CI 6.9-22.3)
Midlife to early late-life blood pressure control could potentially reduce a large proportion (15-20%) of dementia cases by age 80.
Smith et al. (2023) conducted a cohort in Dementia and hypertension. Non-normal blood pressure / hypertension vs. Normal blood pressure was evaluated on Population attributable fraction (PAF) of dementia by age 80 (PAF 15.3%, 95% CI 6.9-22.3). Non-normal blood pressure at ages 45-54 accounted for a population attributable fraction of 15.3% (95% CI 6.9-22.3) for dementia by age 80, with associations persisting through age 75.
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