What question did this study set out to answer?

To determine whether posttransplantation development of antibodies directed against donor HLA mismatches predicts kidney transplant failure.

April 15, 2003Transplantation

Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome1

View Full Paper

Ask AI

Bookmark

Authors

JWJudith WorthingtonUniversity of the West of England SMSusan MartinMichigan Technological University DADalia M. Al-HusseiniUniversity of Manchester

Discussion

Member takes

Implication

Case-control study demonstrates that posttransplant donor HLA-specific antibodies strongly predict graft failure in renal recipients, highlighting their value for early risk detection.

Key Points

To determine whether posttransplantation development of antibodies directed against donor HLA mismatches predicts kidney transplant failure.
Analyzed 112 adult primary renal transplant recipients experiencing graft failure and 123 matched controls with functioning grafts for at least 5 years under equivalent immunosuppression and HLA matching.
Screened pre- and post-transplant sera (at 1, 3, 6 months and annually) using ELISA, cytotoxicity, and flow cytometry to identify HLA class I and class II donor-specific antibodies.
Donor HLA-specific antibodies developed posttransplantation in 50.9% (57/112) of patients in the failure group compared with 1.6% (2/123) of controls (OR = 64.98; 95% CI, 14.78–399.51; P < 0.0001).
Among antibody-positive recipients, donor-specific antibodies were detected prior to transplant failure in 60% of cases, involving class I (n=17), class II (n=14), or both classes (n=3).

Cite This Study

Worthington et al. (2003) studied this question.

synapsesocial.com/papers/6a7dc88bc6a151781133a1db https://doi.org/10.1097/01.tp.0000055833.65192.3b

View Full Paper

Ask AI

Bookmark

Implication

Case-control study demonstrates that posttransplant donor HLA-specific antibodies strongly predict graft failure in renal recipients, highlighting their value for early risk detection.

Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome1

Discussion

Member takes

Implication

Key Points

Cite This Study

Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome1

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider