Why the study?
Does the presence of female sex hormones affect the development and reversal of sodium-dependent hypertension in Dahl salt-sensitive rats?
Population
37 Dahl salt-sensitive rats (12 male, 12 female, 13 ovariectomized female)
Comparison
Dietary sodium increase to 8% NaCl for 2 weeks… vs Time-control rats maintained on 0.15% NaCl diet…
Design
Preclinical
Follow-up
2 weeks on high salt diet, plus reversal period
Authors
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Hypothesis-generating for ovarian hormone protection in salt-sensitive hypertension; leaves open human translation.
Does the presence of female sex hormones affect the development and reversal of sodium-dependent hypertension in Dahl salt-sensitive rats?
Female sex hormones protect against both the development of sodium-dependent hypertension and the development of sodium-independent hypertension in Dahl salt-sensitive rats.
Hinojosa‐Laborde et al. (2000) studied this question.
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