Why the study?
Does treatment with a V1 antagonist (OPC-21,268) and/or captopril reduce systolic blood pressure in male and female Dahl salt-sensitive rats?
Population
Male and female Dahl salt-sensitive rats after 10 days on a high-salt diet
Comparison
OPC-21,268 in food, captopril via subcutaneous… vs Untreated male and female Dahl salt-sensitive rats
Design
Preclinical
Follow-up
12 days
Authors
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Should not alter clinical practice; extends preclinical evidence of sex-specific responses to RAS and vasopressin blockade.
Does treatment with a V1 antagonist (OPC-21,268) and/or captopril reduce systolic blood pressure in male and female Dahl salt-sensitive rats?
Both vasopressin and the renin-angiotensin system contribute to Dahl salt-sensitive hypertension, with significant sex-based differences in treatment response.
Crofton et al. (1993) studied this question.
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