Key result
Ramipril (alone or in combination with a V1 antagonist) prevented the development of salt-induced hypertension in subtotally nephrectomized rats, whereas captopril and V1 antagonist alone did not.
Why the study?
Does treatment with a V1 antagonist or ACE inhibitor prevent the development of salt-induced hypertension in subtotally nephrectomized rats?
Population
Subtotally nephrectomized rats, fed 1% saline
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating in a rat model; leaves open whether ramipril's effect translates to human salt-sensitive hypertension.
Does treatment with a V1 antagonist or ACE inhibitor prevent the development of salt-induced hypertension in subtotally nephrectomized rats?
In a rat model of salt-induced hypertension, ramipril, but not captopril or a V1 antagonist, was effective in preventing the development of hypertension.
Mulinari et al. (1988) studied Salt-induced hypertension. Antivasopressor V1 antagonist, captopril, ramipril, or combination was evaluated on Development of hypertension. Ramipril (alone or in combination with a V1 antagonist) prevented the development of salt-induced hypertension in subtotally nephrectomized rats, whereas captopril and V1 antagonist alone did not.
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